Main Street Bridge
- East Main Street Bridge redirects here
Main Street Bridge or East Main Street Bridge may refer to:
- in Canada
- Main Street Bridge (Winnipeg, Manitoba)
- in the United States
(by state then city)
- Main Street Bridge (New Blaine, Arkansas), listed on the National Register of Historic Places (NRHP) in Logan County, Arkansas
- Main Street Bridge (Florence, Colorado), listed on the NRHP in Fremont County, Colorado
- Main Street Bridge (Stamford, Connecticut), NRHP-listed
- Main Street Bridge (Daytona Beach, Florida); carries County Road 4040 (Volusia County, Florida) across the Atlantic Intracoastal Waterway
- Main Street Bridge (Jacksonville, Florida)
- Main Street Bridge (Charles City, Iowa), listed on the NRHP in Floyd County, Iowa
- East Main Street Bridge (Corbin, Kentucky), listed on the NRHP in Whitley County, Kentucky
- Main Street Bridge (Elkhorn, Nebraska), listed on the NRHP in Douglas County, Nebraska
- Main Street Bridge (Hooksett, New Hampshire)
- Main Street Bridge (Rochester, New York), NRHP-listed
- Scuppernong River Bridge, Columbia, North Carolina, also known as Main Street Bridge, listed on the NRHP in Tyrrell County, North Carolina
- Rainbow Arch Bridge (Valley City, North Dakota), also known as Main Street Bridge, formerly listed on the National Register of Historic Places in Barnes County, North Dakota
- Main Street Bridge (Columbus, Ohio)
- Main Street Bridge (Cleveland, Ohio), a former bridge near the present Cleveland Memorial Shoreway crossing
- Main Street Bridge (Hillsboro, Oregon), a MAX Light Rail bridge in Oregon, United States
- Main Street Bridge (Pawtucket, Rhode Island), NRHP-listed
- Paddock Viaduct, Fort Worth, Texas, also known as Main Street Bridge, listed on the NRHP in Tarrant County, Texas